Standard Operating Procedure (SOP) for Calibration of Balance

Cleaning of High Performance Liquid Chromatography (HPLC)

1. Purpose of Calibration of Balance

The purpose of this Standard Operating Procedure (SOP) for Calibration of Balance is to establish guidelines for the calibration of balances within [Company Name]. This procedure ensures the accuracy and precision of weight measurements.

2. Scope of Calibration of Balance

This SOP for Calibration of Balance applies to all personnel responsible for using and maintaining balances within [Company Name]. It covers the procedures for balance calibration, calibration weights, environmental conditions, and recordkeeping.

3. Definitions

3.1 Balance:

An instrument used to measure the mass of an object accurately.

4. Safety Precautions and Personal Protective Equipment (PPE)

4.1. PPE Requirements

4.1.1 Personnel conducting balance calibration must wear appropriate PPE, including lab coats, safety goggles, and gloves.

4.1.2 Ensure that PPE is in good condition and properly fitted.

5. Equipment and Materials

5.1. Calibration Weights

5.1.1 Ensure the availability of calibrated weights appropriate for the balance being calibrated.

5.1.2 Calibrated weights should have a certificate of calibration traceable to national standards.

5.2. Environmental Conditions

5.2.1 Perform balance calibrations in a controlled environment with stable temperature and humidity conditions.

5.2.2 The temperature should be within the range specified by the balance manufacturer.

6. Balance Calibration Procedure

6.1. Preliminary Checks

6.1.1 Ensure that the balance is clean and free from any debris or substances that could affect calibration.

6.1.2 Check that the balance is level using a spirit level if necessary.

6.2. Calibration Setup

6.2.1 Place the calibrated weights carefully on the balance pan.

6.2.2 Ensure that the weights are positioned evenly and securely.

6.3. Calibration Process

6.3.1 Record the weight readings displayed by the balance for each calibration weight used.

6.3.2 Repeat the calibration process with multiple weights to ensure accuracy.

6.4. Evaluation

6.4.1 Calculate the measurement error for each weight used in the calibration.

6.4.2 Ensure that the measurement error falls within the acceptable range defined by the balance manufacturer or relevant standards.

7. Documentation and Recordkeeping

7.1. Calibration Records

7.1.1 Maintain detailed records of each calibration session, including the date, time, calibration weights used, measurement error, and any adjustments made.

7.1.2 Ensure that all records are signed, dated, and readily accessible for review.

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